期刊
BIOSYSTEMS
卷 171, 期 -, 页码 20-25出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biosystems.2018.05.007
关键词
Drug delivery; Subcellular processes; Gene expression; Mean-field kinetic equations
资金
- Swedish Foundation for Strategic Research [IRC15-0065]
- Russian Academy of Sciences
- Federal Agency for Scientific Organizations [0303-2016-0001]
Nanocarrier-mediated delivery and release of short non-coding RNA (e.g., miRNA or siRNA) into the cells with subsequent suppression of the populations of some of the mRNAs and proteins is of interest in the context of the development of a new generation of drugs. Bearing in mind such applications, the author shows the specifics of the corresponding transient kinetics by using three generic models without and with feedback resulting in bistability in the gene expression. In the absence of feedback, the suppression of the mRNA and protein population is transient. In the case of bistable kinetics, non-coding RNA can induce transition from the initial steady state to another steady state. The duration of this transition can be much longer than the time scale characterizing the drop of the non-coding RNA population. Quantitatively, the effect of the delivered non-coding RNA on gene expression can be appreciable if the maximum non-coding RNA population in the cytoplasm is comparable to or above 1000. All these conclusions have been drawn on the basis of calculations performed with the kinetic parameters typical for human cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据