期刊
BIOSYSTEMS
卷 164, 期 -, 页码 155-166出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biosystems.2017.09.006
关键词
Aminoacyl-tRNA synthetase; RNA World; Autocatalysis; GRT systems; Quasi-species bifurcation
资金
- National Institute of General Medical Sciences [R01-78227]
- John Templeton Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM078227] Funding Source: NIH RePORTER
Differential equations for error-prone information transfer (template replication, transcription or translation) are developed in order to consider, within the theory of autocatalysis, the advent of coded protein synthesis. Variations of these equations furnish a basis for comparing the plausibility of contrasting scenarios for the emergence of specific tRNA aminoacylation, ultimately by enzymes, and the relationship of this process with the origin of the universal system of molecular biological information processing embodied in the Central Dogma. The hypothetical RNA World does not furnish an adequate basis for explaining how this system came into being, but principles of self-organisation that transcend Darwinian natural selection furnish an unexpectedly robust basis for a rapid, concerted transition to genetic coding from a peptide RNA world. (C) 2017 Elsevier B.V. All rights reserved.
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