期刊
BIOSENSORS & BIOELECTRONICS
卷 113, 期 -, 页码 32-38出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2018.04.051
关键词
Electrolyte-Gated OFET; Diazonium salt; 2,4-dichlorophenoxyacetic acid; 2,4-D; Inununosensor; Molecular modelling
类别
资金
- 911 USTH grant scheme
- University Paris Diderot
We investigated an Electrolyte-Gated Organic Field-Effect transistor based on poly(N-alkyldiketopyrrolo-pyrrole dithienylthieno[3,2-b] thiophene) as organic semiconductor whose gate electrode was functionalized by electrografting a functional diazonium salt capable to bind an antibody specific to 2,4-dichlorophenoxyacetic acid (2,4-D), an herbicide well-known to be a soil and water pollutant. Molecular docking computations were performed to design the functional diazonium salt to rationalize the antibody capture on the gate surface. Sensing of 2,4-D was performed through a displacement immunoassay. The limit of detection was estimated at around 23 fM.
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