4.8 Article

A photoelectrochemical aptasensor based on a 3D flower-like TiO2-MoS2-gold nanoparticle heterostructure for detection of kanamycin

期刊

BIOSENSORS & BIOELECTRONICS
卷 112, 期 -, 页码 193-201

出版社

ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2018.04.041

关键词

TiO2-MoS3-AuNP composite; Photoelectrochemical aptasensor; Kanamycin detection; Visible light excitation

资金

  1. National Natural Science Foundation of China [U1504215, 21576071]
  2. International Science and Technology Cooperative Project - Department of Science and Technology of Henan Province [172102410042]

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In this work, a sensitive photoelectrochemical aptasensor was developed for kanamycin detection using an enhanced photocurrent response strategy, which is based on the surface plasmon resonance effect of gold nanoparticles deposited on a 3D TiO2-MoS2 flower-like heterostructure. A significant aspect of this development lies in the photoelectrochemical and morphological features of the unique ternary composite, which have contributed to the excellent performance of the sensor. To develop an aptasensor, mercapto-group modified aptamers were immobilised on the photoactive composite as a recognition unit for kanamycin. The TiO2-MoS2AuNP composite was demonstrated to accelerate the electron transfer, increase the loading of aptamers and improve the visible light excitation of the sensor. Under optimal conditions, the aptasensor exhibited a dynamic range from 0.2 nM to 450 nM of kanamycin with a detection limit of 0.05 nM. Overall, we have successfully synergised both the electrical and the optical merits from individual components to form a ternary composite, which was then demonstrated as an effective scaffold for the development of PEC biosensors.

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