期刊
BIOSCIENCE REPORTS
卷 38, 期 -, 页码 -出版社
PORTLAND PRESS LTD
DOI: 10.1042/BSR20180304
关键词
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资金
- Coordination for the Improvement of Higher Education Personnel (CAPES)
- National Council for Scientific and Technological Development (CNPq) [483710/2013-0]
- Foundation for Research Support of Rio Grande do Norte (FAPERN) [0887/2015]
We investigated the inflammatory effect of a pellet-diet with high glycemic index and load (HGLI) on the histological organization of adipocytes, intestinal epithelium, and fat in liver and pancreas in adult male Wistar rats. Two groups (n= 10) received for 17 weeks: (1) HGLI diet or (2) Standard diet (Labina (R)). Histological analyses of adipose tissue, jejunum, liver, and pancreas were performed. Stereology analysis, visceral adiposity index, gene expression, and immunohistochemistry of tumor necrosis factor-alpha (TNF-alpha) in visceral adipose tissue and plasma TNF-alpha were also assessed. The HGLI diet-induced hypertrophy of adipocytes with adipocyte volume density equal to 97.0%, cross-sectional area of adipocytes equivalent to 1387 mu m(2) and a total volume of adipocytes of 6.97 cm(3) an elevation of 8%, 25%, and 58%, respectively. Furthermore, the HGLI diet increased liver and pancreatic fat deposition, altered and inflamed the intestinal epithelia, and increased TNF-alpha gene expression (P=0.014) with a positive immunostaining in visceral adipose tissue and high plasma TNF-alpha in comparison with standard diet. The results suggest that this diet was able to generate changes commonly caused to solid diets with high fat or fructose-rich beverages. To the best of our knowledge, this is the first report in the literature concerning the properties of low-cost, sucrose-rich pellet-diet presenting high glycemic index and high glycemic load efficient on the development of obesity complications in Wistar rats that were subjected to diet-induced obesity. Therefore, the HGLI pellet-diet may be considered an effective tool to be used by the scientific community in experimental research.
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