期刊
BIORESOURCE TECHNOLOGY
卷 258, 期 -, 页码 345-353出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2018.03.001
关键词
L-Malic acid; Biosynthesis; Renewable resources; Metabolic engineering; Carbon dioxide
资金
- Jiangsu Province Natural Science Foundation for Youths [BK20170993]
- Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture
- Key Science and Technology Project of Jiangsu Province [BE2016389]
- National Natural Science Foundation of China [21706125, 21727818, 21706124, 31700092]
- Project of State Key Laboratory of Materials-Oriented Chemical Engineering [KL16-08]
- Top-notch Academic Programs Project of Jiangsu Higher Education Institutions, TAPP [PPZY2015B155]
Malic acid (2-hydroxybutanedioic acid) is a four-carbon dicarboxylic acid, which has attracted great interest due to its wide usage as a precursor of many industrially important chemicals in the food, chemicals, and pharmaceutical industries. Several mature routes for malic acid production have been developed, such as chemical synthesis, enzymatic conversion and biological fermentation. With depletion of fossil fuels and concerns regarding environmental issues, biological production of malic acid has attracted more attention, which mainly consists of three pathways, namely non-oxidative pathway, oxidative pathway and glyoxylate cycle. In recent decades, metabolic engineering of model strains, and process optimization for malic acid production have been rapidly developed. Hence, this review comprehensively introduces an overview of malic acid producers and highlight some of the successful metabolic engineering approaches.
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