期刊
FEMS YEAST RESEARCH
卷 16, 期 2, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsyr/fov110
关键词
Candida glabrata; virulence; evolution; Nakaseomyces; Candida
资金
- Spanish Ministry of Economy and Competitiveness - European Regional Development Fund (ERDF) [SEV-2012-0208, BIO2012-37161]
- European Union
- ERC Seventh Framework Programme [FP7-PEOPLE-2013-ITN-606786, ERC-2012-StG-310325]
- European Union's Horizon research and innovation programme under the Marie Sklodowska-Curie grant agreement [H2020-MSCA-ITN-2014-642095]
- ICREA Funding Source: Custom
The yeast Candida glabrata is an opportunistic human fungal pathogen whose incidence has increased in the last two decades. Despite its name, this yeast is only distantly related to the model fungal pathogen C. albicans, and more closely related to Saccharomyces cerevisiae and other yeasts that underwent an ancient whole-genome duplication. Understanding what specific traits make C. glabrata a successful opportunistic pathogen within a clade of mostly innocuous yeasts, and how these compare to virulence traits in distant pathogens such as C. albicans is a focus of intense research. From an evolutionary perspective, uncovering how the ability to infect humans has emerged multiple, independent times in different lineages may reveal new disease mechanisms and provide us with the capacity to predict which genomic features in a clade may confer a higher potential to develop virulence against humans.
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