期刊
BIOENGINEERING & TRANSLATIONAL MEDICINE
卷 1, 期 1, 页码 94-102出版社
WILEY
DOI: 10.1002/btm2.10007
关键词
-
资金
- HHS [CA 188833-02]
Despite major advances in the field of radiotherapy, healthy tissue damage continues to constrain the dose that can be prescribed in cancer therapy. Gold nanoparticles (GNPs) have been proposed as a solution to minimize radiation-associated toxicities by enhancing the radiation dose delivered locally to tumor cells. In the current study, we investigated the application of third-generation GNPs in two-dimensional (2D) and three-dimensional (3D) cell cultures and whether there is synergy between the nanoparticles and kilo-or mega-voltage radiation to cause augmented cytotoxicity. The 10-nm GNPs were found to be nontoxic in both 2D and 3D in vitro cultures of colon cancer cells at concentrations of up to 10-25 mu g/ml. There was a significant increase in cell survival fraction reduction following exposure to 1 Gy of kilo-voltage (18.3%) and 2 Gy of mega-voltage (35.3%) radiation when the cells were incubated with 50 mu g/ml of GNPs. The biocompatibility of the GNPs combined with their substantial synergy with radiation encourages further investigations into their application in targeted cancer treatment.
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