期刊
BIOFABRICATION
卷 8, 期 1, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1758-5090/8/1/015011
关键词
three-dimensional (3D) bioprinting; dispensing module; thermal degradation; syringe type; filament type; poly lactic-co-glycolic acid (PLGA) scaffold
资金
- National Research Foundation of Korea (NRF) - Korean government (MSIP) [2010-0018294]
- Institute for Information & communications Technology Promotion (IITP) - Korean government (MSIP) [R0190-15-2072]
- Ministry of Public Safety & Security (MPSS), Republic of Korea [R0190-15-2072] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Recently, numerous three-dimensional (3D) bioprinting systems have been introduced for the artificial regeneration of tissues. Among them, the extrusion-based dispensing module is the most widely used because of the processability it gives various biomaterials. The module uses high forces and temperature to dispense materials through a micro-nozzle. Generally, the harsh conditions induce thermal degradation of the material in the dispensing procedure. The thermal degradation affects the properties of the materials, and the change of the properties should be carefully controlled, because it severely affects the regeneration of tissues. Therefore, in this research, the relationship between the dispensing module and the thermal degradation of material was investigated. Extrusion-based dispensing modules can be divided into the syringe type (ST) and filament type (FT) based on working principles. We prepared a poly lactic-co-glycolic acid (PLGA) scaffold with the two methods at various time points. Then, the characteristics of the printed scaffolds were assessed by measuring molecular weight (M-w), glass transition temperature (T-g), in vitro degradation, compressive modulus, and cytocompatibility. The results showed that the PLGA scaffold with the FT dispensing module maintained its properties regardless of printing time points. In contrast, severe thermal degradation was observed in the scaffold group prepared by the ST dispensing module. Consequentially, it was obvious that the FT dispensing module was more suitable for producing scaffolds without severe thermal degradation.
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