期刊
FERTILITY AND STERILITY
卷 103, 期 5, 页码 1261-+出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2015.02.001
关键词
Perfluoroalkyl substances; PFOS; E-2; progesterone; endocrine disruptors
资金
- National Institutes of Health (NIH) [T32AI083206, K12 ES019852, P30 ES001247]
- Norwegian Cancer Society [49 258 05087]
- Foundation for the Norwegian Health and Rehabilitation Organizations [59010-2000/2002/2002]
- South-East Norwegian Health Authority [2012064]
- Norwegian Research Council [3215]
Objective: To examine associations between environmental exposure to perfluoroalkyl substances (PFASs) and ovarian hormone concentrations in naturally cycling women. Design: E2 and P were measured in saliva samples collected daily for a single menstrual cycle and concentrations of PFASs (including perfluoroctane sulfonate [PFOS] and perfluoroctanoic acid) were measured in serum samples collected during the same cycle. Setting: Not applicable. Patient(s): A total of 178 healthy, naturally cycling women, aged 25-35 years. Intervention(s): None. Main Outcome Measure(s): Mean follicular E-2 (cycle days -7 to -1, where 0 is the day of ovulation); mean luteal P (cycle days +2 to 10). Result(s): Among nulliparous, but not parous women, PFOS concentrations were inversely associated with E-2 (beta = -0.025, 95% CI -0.043, -0.007) and P (beta = -0.027, 95% CI - 0.048, -0.007). Similar, but weaker results were observed for perfluorooctanesulfonic acid. No associations were observed between other PFASs (including perfluoroctanoic acid) and ovarian steroid concentrations, nor were any associations noted in parous women. Conclusion(s): Our results demonstrate that PFOS and perfluorooctanesulfonic acid may be associated with decreased production of E-2 and P in reproductive age women. These results suggest a possible mechanism by which PFASs affect women's health, and underscore the importance of parity in research on PFASs and women's reproductive health. (C) 2015 by American Society for Reproductive Medicine.
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