期刊
FERTILITY AND STERILITY
卷 103, 期 2, 页码 317-322出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2014.12.115
关键词
Fertility; telomeres; oocyte competency; aging; polar body
The oocyte is the major determinant of embryo developmental competence in women. It delivers half the chromosomal complement to the embryo, but the maternal and paternal genomes are neither symmetrical nor equal in their contributions to embryo fate. Unlike the paternal genome, the maternal genome carries a heavy footprint of parental aging. Indeed, age is the single best predictor of reproductive outcome in women, and the oocyte is the locus of reproductive aging in women. The oocyte transmits not only the mother's nuclear but also her mitochondrial genome to the embryo, and mitochondrial DNA is known to be especially susceptible to aging. Morphological studies of the oocyte and its associated cumulus corona cells provide only marginal value in the assessment of embryo developmental potential. A number of novel technologies, however, have improved the noninvasive assessment of oocyte quality. Moreover, during maturation, the oocyte ejects half its homologous chromosomes into the first polar body and half its chromatids into the second polar body. Polar body DNA is remarkably similar to that of the oocyte, so analysis of polar body DNA provides a window into the oocyte's genome and telomeres, which may enhance prediction of embryo developmental competence. (C) 2015 by American Society for Reproductive Medicine.
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