期刊
NATURE PLANTS
卷 2, 期 3, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NPLANTS.2016.13
关键词
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资金
- Deutsche Forschungsgemeinschaft [BA 4769/2-1]
- Ministry of Education, Youth and Sports of the Czech Republic (National Program for Sustainability I) [LO1204]
- Grant Agency of the Czech Republic [14-34792S]
- National Research Foundation of Korea [500-20140212]
- University of Potsdam
- MPI of Molecular Plant Physiology
- Ministry of Education, Youth and Sports of the Czech Republic ('Navrat' programme) [LK21306]
Gibberellins (GAs) and brassinosteroids (BRs) are important phytohormones that control plant development and responses to environmental cues by involving DELLA proteins and BRASSINAZOLE-RESISTANT1 (BZR1) respectively as key transcription factors. Here, we reveal a new role for JUNGBRUNNEN1 (JUB1) as a transcriptional regulator of GA/BR signalling in Arabidopsis thaliana. JUB1 directly represses the hormone biosynthesis genes GA3ox1 and DWARF4 (DWF4), leading to reduced levels of GAs and BRs and typical GA/BR deficiency phenotypes exhibiting short hypocotyls, dwarfism, late flowering and male sterility. JUB1 also directly represses PHYTOCHROME INTERACTING FACTOR4 (PIF4), a transcription factor connecting hormonal and environmental stimuli. On the other hand, JUB1 activates the DELLA genes GA INSENSITIVE (GAI) and RGA-LIKE 1 (RGL1). In addition, BZR1 and PIF4 act as direct transcriptional repressors upstream of JUB1, establishing a negative feedback loop. Thus, JUB1 forms the core of a robust regulatory module that triggers DELLA accumulation, thereby restricting cell elongation while concomitantly enhancing stress tolerance.
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