期刊
BIOORGANIC CHEMISTRY
卷 80, 期 -, 页码 555-559出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2018.06.034
关键词
Lipase; Knoevenagel condensation; Aromatic aldehyde; Xanthone; Catalysis
资金
- National Natural Science Foundation of China [21676143]
- key laboratory of Materials-Oriented Chemical Engineering [ZK201603]
- Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture
- Qing Lan Project of Jiangsu Province
Based on the screening of biocatalysts and reaction conditions including organic solvent, water content, lipase loading, reaction temperature and time, lipase TLIM exhibited the prominent promiscuity for the Knoevenagel-Michael cascade reactions of 1, 3-diketones with aromatic aldehydes to synthesize xanthone derivatives. This procedure provides satisfactory advantages such as environmental begin, simple work-up, generality, obtaining in excellent yields (80-97%), and potential for recycling of biocatalyst.
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