期刊
BIOORGANIC CHEMISTRY
卷 79, 期 -, 页码 277-284出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2018.05.008
关键词
3-Aminocoumarin derivatives; 7-Amino-4-methylcoumarin derivatives; DPP-IV inhibition; Anticancer activity
资金
- Department of Science & Technology, Government of India [SR/WOS-A/CS-1028/2014]
DPP-IV a moonlighting protein has immerged as promising pathway to control Type 2 diabetes as well as found to play key role in earlier stages of cancer. Here we have reported design, synthesis and applications of aminocoumarin derivatives as DPP-IV inhibitors. Compounds have been synthesized and studied for their DPP-IV inhibition activity. Three compounds have shown moderate inhibition at 100 mu M concentration. All compounds were also screened for their anticancer activity against A549 (Lung cancer cell line), MCF-7 (Breast cancer cell line) using MTT assay. One of the compounds has shown very good anticancer activity with IC50 value 24 +/- 0.1 nM against A549 cell line.
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