期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 28, 期 12, 页码 2206-2209出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2018.04.067
关键词
Pentapeptide; Cyanobacterium; Astrocyte differentiation; Neural stem cells; Marine natural products
资金
- Ministry of Education, Science, Sports, and Technology (MEXT), Japan
- JSPS KAKENHI [26221204, 25303008, 19310138]
- Shenzhen Peacock Plan [KQTD2015071714043444]
- JSPS Core-to-Core Program, A. Advanced Research Networks
- Waseda University
Kakeromamide A (1), a new cyclic pentapeptide encompassing a thiazole ring moiety and a beta-amino acid, was isolated from the marine cyanobacterium Moorea bouillonii. Its structure was elucidated by the spectral analysis and the modified Marfey's method. Compound 1 induced differentiation of neural stem cells into astrocytes at the concentration of 10 mu M. (C) 2018 Published by Elsevier Ltd.
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