期刊
CURRENT ONCOLOGY
卷 23, 期 -, 页码 S23-S32出版社
MULTIMED INC
DOI: 10.3747/co.23.3080
关键词
Cannabinoids; apoptosis; autophagy; cell proliferation; angiogenesis; cell signalling; combination therapy
类别
资金
- Spanish Ministry of Economy and Competitiveness
- Fondo Europeo de Desarrollo Regional [PI12/02248, PI15/0339, FR2009-0052, IT2009-0053, PI11/00295]
- Comunidad de Madrid [S2011/BMD-2308]
- GW Pharmaceuticals
- Fundacion Mutua Madrilena [AP101042012]
- Fundacio La Marato de TV3 [20134031]
In addition to the well-known palliative effects of cannabinoids on some cancer-associated symptoms, a large body of evidence shows that these molecules can decrease tumour growth in animal models of cancer. They do so by modulating key cell signalling pathways involved in the control of cancer cell proliferation and survival. In addition, cannabinoids inhibit angiogenesis and decrease metastasis in various tumour types in laboratory animals. In this review, we discuss the current understanding of cannabinoids as antitumour agents, focusing on recent discoveries about their molecular mechanisms of action, including resistance mechanisms and opportunities for their use in combination therapy. Those observations have already contributed to the foundation for the development of the first clinical studies that will analyze the safety and potential clinical benefit of cannabinoids as anticancer agents.
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