期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 28, 期 4, 页码 642-645出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2018.01.028
关键词
Farnesol; beta-Lactam antibiotics; Methicillin-resistant Staphylococcus aureus (MRSA); Antimicrobial activity; Potentiation
资金
- National Institutes of Health [AI104987]
Farnesol, a sesquiterpene alcohol, potentiates the activity of beta-lactam antibiotics against antibiotic-resistant bacteria. We document that farnesol and two synthetic derivatives (compounds 2 and 6) have poor antibacterial activities of their own, but they potentiate the activities of ampicillin and oxacillin against Staphylococcus aureus strains (including methicillin-resistant S. aureus). These compounds attenuate the rate of growth of bacteria, which has to be taken into account in assessment of the potentiation effect. (C) 2018 Elsevier Ltd. All rights reserved.
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