期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 28, 期 4, 页码 668-672出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2018.01.018
关键词
Senkyunolide analogues; Neuroprotective agents; Acute cerebral ischemia; Furoxan
资金
- National Natural Science Foundation of China [81460526, 81560662]
- Jiangxi Provincial Department of Science and Technology [20171BAB205103]
- Hongcheng Haiou Plan of Nanchang City
- Health and Family Planning Commission of Jiangxi Province [2016A013]
A class of senkyunolide analogues bearing benzofuranone fragment were designed, synthesized and evaluated for their neuroprotective effect in models of oxygen glucose deprivation (OGD) and oxidative stress. All tested compounds showed neuroprotection profile based on the cell viability assay. In particular, derivatives 1f-1i possessing furoxan-based nitric oxide releasing functionality exhibited significant biological activities in OGD models. More importantly, compound 1g containing short linker with furoxan displayed the most potent neuroprotection at the concentration of 100 mu M (cell survival up to 145.2%). Besides, 1g also showed the middle level neuroprotective effect in model of oxidative stress. (C) 2018 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据