期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 28, 期 6, 页码 987-992出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2018.02.049
关键词
Factor XIa inhibitors; FXIa; Thrombosis; Pyridazine; Pyridazinone
Pyridazine and pyridazinone derivatives were designed and synthesized as coagulation factor XIa inhibitors. Potent and selective inhibitors with single digit nanomolar affinity for factor XIa were discovered. Selected inhibitors demonstrated moderate oral bioavailability. (C) 2018 Elsevier Ltd. All rights reserved.
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