期刊
DATA IN BRIEF
卷 6, 期 -, 页码 101-111出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dib.2015.11.047
关键词
Schizosaccharomyces pombe; Nitric oxide; Nitrosative stress; Differential display analysis
资金
- Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain
- DBT, Govt. of India [BT/PR12551/BRB/10/02/2009]
- CSIR, Govt. of India
- DBT, Govt. of India
Excess production of nitric oxide (NO) and reactive nitrogen intermediates (RNIs) causes nitrosative stress on cells. Schizosaccharomyces pombe was used as a model to study nitrosative stress response. In the present data article, we have used differential display to identify the differentially expressed genes in the fission yeast under nitrosative stress conditions. We have used pure NO donor compound detaNONOate at final concentrations of 0.1 mM and 1 mM to treat the cells for 15 min alongside control before studying their gene expression profiles. At both the treated conditions, we identified genes which were commonly repressed while several genes were induced upon both 0.1 mM and 1 mM treatments. The differentially expressed genes were further analyzed in DAVID and categorized into several different pathways. (C) 2015 The Authors. Published by Elsevier Inc.
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