期刊
BIOMOLECULES & THERAPEUTICS
卷 26, 期 4, 页码 350-357出版社
KOREAN SOC APPLIED PHARMACOLOGY
DOI: 10.4062/biomolther.2017.133
关键词
Phagocytosis; Astrocytes; Microglia; Synapse elimination; Neurodegenerative disease
资金
- National Research Foundation of Korea (NRF) grant - Korean government (MSIP) [NRF-2016M3C7A1905391, NRF-2016R1C1B3006969]
Glial cells are receiving much attention since they have been recognized as important regulators of many aspects of brain function and disease. Recent evidence has revealed that two different glial cells, astrocytes and microglia, control synapse elimination under normal and pathological conditions via phagocytosis. Astrocytes use the MEGF10 and MERTK phagocytic pathways, and microglia use the classical complement pathway to recognize and eliminate unwanted synapses. Notably, glial phagocytosis also contributes to the clearance of disease-specific protein aggregates, such as beta-amyloid, huntingtin, and a-synuclein. Here we reivew recent findings showing that glial cells are active regulators in brain functions through phagocytosis and that changes in glial phagocytosis contribute to the pathogenesis of various neurodegenerative diseases. A better understanding of the cellular and molecular mechanisms of glial phagocytosis in healthy and diseased brains will greatly improve our current approach in treating these diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据