期刊
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
卷 1, 期 1, 页码 7-16出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.synbio.2016.03.002
关键词
Avermectins; Metabolic engineering; Streptomyces avermitilis; Synthetic biology
资金
- National Program on Key Basic Research Project (973 program) [2013CB734000, 2012CB725203]
- National Natural Science Foundation of China [31170095, 31000057, 31100075]
- Ministry of Science and Technology of the People's Republic of China [2011ZX11102-011-11, 2013ZX10005004-005]
- China Ocean Mineral Resources R D Association [DY125-15-T-07]
- National Distinguished Young Scholar Program in China
The 2015 Nobel Prize in Physiology or Medicine has been awarded to avermectins and artemisinin, respectively. Avermectins produced by Streptomyces avermitilis are excellent anthelmintic and potential antibiotic agents. Because wild-type strains only produce low levels of avermectins, much research effort has focused on improvements in avermectin production to meet the ever increasing demand for such compounds. This review describes the strategies that have been widely employed and the future prospects of synthetic biology applications in avermectin yield improvement. With the help of genome sequencing of S. avermitilis and an understanding of the avermectin biosynthetic/regulatory pathways, synthetic and systems biotechnology approaches have been applied for precision engineering. We focus on the design and synthesis of biological chassis, parts, devices, and modules from diverse microbes to reconstruct and optimize their dynamic processes, as well as predict favorable effective overproduction of avermectins by a 4Ms strategy (Mine, Model, Manipulation, and Measurement). (C) 2016 Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
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