期刊
BIOMOLECULES & THERAPEUTICS
卷 26, 期 1, 页码 69-80出版社
KOREAN SOC APPLIED PHARMACOLOGY
DOI: 10.4062/biomolther.2017.185
关键词
Cancer; Metabolism; Epigenetics; Acetylation; Methylation; Metastasis
资金
- National Research Foundation of Korea - Ministry of Science, ICT & Future Planning [NRF-2013R1A1A 1006638, NRF-2013M3A9B5076422, NRF-2016R1A5A2012284]
- KRIBB Research Initiative Program
- National Research Foundation of Korea [2013M3A9B5076422] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Cancer cells reprogram cellular metabolism to support the malignant features of tumors, such as rapid growth and proliferation. The cancer promoting effects of metabolic reprogramming are found in many aspects: generating additional energy, providing more anabolic molecules for biosynthesis, and rebalancing cellular redox states in cancer cells. Metabolic pathways are considered the pipelines to supply metabolic cofactors of epigenetic modifiers. In this regard, cancer metabolism, whereby cellular metabolite levels are greatly altered compared to normal levels, is closely associated with cancer epigenetics, which is implicated in many stages of tumorigenesis. In this review, we provide an overview of cancer metabolism and its involvement in epigenetic modifications and suggest that the metabolic adaptation leading to epigenetic changes in cancer cells is an important non-genetic factor for tumor progression, which cooperates with genetic causes. Understanding the interaction of metabolic reprogramming with epigenetics in cancers may help to develop novel or highly improved therapeutic strategies that target cancer metabolism.
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