期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 105, 期 -, 页码 195-203出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2018.05.126
关键词
Chalcone; Apoptosis; Cancer; Surflexdock
资金
- National Natural Science Foundation of China [81570399, 81773735]
- National Key Research and Development Program of China- Traditional Chinese Medicine Modernization Research project [SQ2017YFC170204]
- Heilongjiang Outstanding Youth Science Fund [JJ2017JQ0035]
Apoptosis is an important biological phenomenon, which affects many diseases, such as cancer and Alzheimer's disease. In the present study, we observed that chalcone 9X, an aromatic ketone, induced apoptosis of human hepatic and lung cancer cells and inhibited cancer cell migration and invasion. This compound strongly suppressed the growth of tumor in a mouse model of xenograft tumors. The anticancer activity of chalcone 9X was equivalent to 5-fluorouracil (5 FU) as a positive control agent, whereas the toxic effect of chalcone 9X in non-cancer cells was weaker than 5 FU. Molecular docking results showed that chalcone 9X could act on the active sites of pro-apoptotic proteins capspases-3 and -8 to induce apoptotic death of cancer cells. Our findings suggest that chalcone 9X might be considered a candidate compound of novel anticancer drug in the future.
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