The first direct C-3 alkenylation of N-substituted-4-hydroxy-2-pyridones with unactivated alkenes has been achieved under conventional palladium acetate catalysis. The presented protocol enables the efficient production of functionalized furo[3,2-c]pyridones-2 when terminal alkenes are utilized and 3-alkenyl-4-hydroxy-2-pyridones when more substituted reaction partners are involved. The mild reaction conditions allow easy, scalable access to pyridone derivatives that resemble core structures isolated from natural alkaloids.
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