Variable speed of sound compensation in the linear-array photoacoustic tomography using a multi-stencils fast marching method

Despite the promising clinical application of linear-array photoacoustic tomography, it has been shown the variable speed of sound would severely affect the photoacoustic imaging quality, resulting in the target deterioration and inaccurate depth positioning in the conventional constant speed assumed delay and sum (DAS) reconstruction. By contrast, multi-stencils fast marching (MSFM) method is able to produce accurate time delay map for the tissue with inhomogeneous acoustic speed. This study explored the combination of DAS reconstruction algorithm with the MSFM approach to reduce the imaging distortions due to the speed spatial variation, where the target structure and target position in depth could be measured more precisely. To validate the performance of the proposed method, numerical, phantom, and in vivo photoacoustic studies were conducted with the qualitative and quantitative analysis, especially in the detection of mouse deep brain tumor with an intact skull. (C) 2018 Elsevier Ltd. All rights reserved.