期刊
BIOMATERIALS
卷 153, 期 -, 页码 85-101出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2017.06.022
关键词
High-throughput system; Cell-biomaterial interactions; Cellular microenvironments; Biomolecule delivery; Biomaterial screening; High-throughput biosensor
资金
- National Science Foundation [EFRI-1240443]
- Ohio Biomedical Research Commercialization Program [TECG20150782]
- ONR PECASE Award
- Department of Defense Congressionally Directed Medical Research Programs [OR110196]
- National Institutes of Health [AR066193, AR063194, AR053733, AR069564, AR007505, AR061265, AR057837, DE022376, DE021468, DE025899, EB023907]
- National Research Foundation of Korea (NRF) - Ministry of Education [2016R1A6A3A03006491]
- KIST [2E26900]
- Innovative Research Incentives Scheme Veni of the Netherlands Organization for Scientific Research (NWO) [14328]
- NATIONAL CANCER INSTITUTE [P30CA016042] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI053733] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [T32AR007505, R21AR061265, R01AR063194, R01AR057837, R01AR069564, R01AR066193] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB023907] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE021468, R56DE022376] Funding Source: NIH RePORTER
The rapid development of new biomaterials and techniques to modify them challenge our capability to characterize them using conventional methods. In response, numerous high-throughput (HT) strategies are being developed to analyze biomaterials and their interactions with cells using combinatorial approaches. Moreover, these systematic analyses have the power to uncover effects of delivered soluble bioactive molecules on cell responses. In this review, we describe the recent developments in HT approaches that help identify cellular microenvironments affecting cell behaviors and highlight HT screening of biochemical libraries for gene delivery, drug discovery, and toxicological studies. We also discuss HT techniques for the analyses of cell secreted biomolecules and provide perspectives on the future utility of HT approaches in biomedical engineering. Published by Elsevier Ltd.
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