期刊
BIOMATERIALS
卷 178, 期 -, 页码 383-400出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2018.05.003
关键词
Citric acid; Elastomer; Antimicrobial; Osteogenic differentiation; Metabolic regulation; Regenerative engineering
资金
- U.S. National Institutes of Health [CA182670, EB024829, AR071316]
- National Science Foundation [CMMI 1537008]
- National Natural Science Foundation of China [81460210]
- Department of Science and Technology of Yunnan Province of China [2017FA035]
- NATIONAL CANCER INSTITUTE [R01CA182670] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR071316] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB024829] Funding Source: NIH RePORTER
Leveraging the multifunctional nature of citrate in chemistry and inspired by its important role in biological tissues, a class of highly versatile and functional citrate-based materials (CBBs) has been developed via facile and cost-effective polycondensation. CBBs exhibiting tunable mechanical properties and degradation rates, together with excellent biocompatibility and processability, have been successfully applied in vitro and in vivo for applications ranging from soft to hard tissue regeneration, as well as for nanomedicine designs. We summarize in the review, chemistry considerations for CBBs design to tune polymer properties and to introduce functionality with a focus on the most recent advances, biological functions of citrate in native tissues with the new notion of degradation products as cell modulator highlighted, and the applications of CBBs in wound healing, nanomedicine, orthopedic, cardiovascular, nerve and bladder tissue engineering. Given the expansive evidence for citrate's potential in biology and biomaterial science outlined in this review, it is expected that citrate based materials will continue to play an important role in regenerative engineering. (C) 2018 Elsevier Ltd. All rights reserved.
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