期刊
BIOMATERIALS
卷 167, 期 -, 页码 121-131出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2018.03.003
关键词
Hair follicle; Neogenesis; Protein factor; Reprogram; Extracellular matrix; Regeneration
资金
- Taiwan Bio-Development Foundation (TBF)
- Taiwan Ministry of Science and Technology [103-2325-B-002-008, 103-2628-B002-004-MY3, 104-2627-M-002-012, 102-2314-B-002-046-MY3, 104-2113-M-001-005-MY3]
- Taiwan Ministry of Science and Technology (SPARK program)
- National Taiwan University Hospital [NTU-CDP-103R7879, NTU-CDP-1104R7879]
- National Taiwan University grant [104R7602D4]
- Asia-Pacific La Roche-Posay Foundation
- NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases grant [R01-AR067273]
- Pew Charitable Trust [00029641]
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR067273] Funding Source: NIH RePORTER
Organ development is a sophisticated process of self-organization. However, despite growing understanding of the developmental mechanisms, little is known about how to reactivate them postnatally for regeneration. We found that treatment of adult non-hair fibroblasts with cell-free extract from embryonic skin conferred upon them the competency to regenerate hair follicles. Proteomics analysis identified three secreted proteins enriched in the embryonic skin, apolipoprotein-A1, galectin-1 and lumican that together were essential and sufficient to induce new hair follicles. These 3 proteins show a stage-specific co-enrichment in the perifolliculogenetic embryonic dermis. Mechanistically, exposure to embryonic skin extract or to the combination of the 3 proteins altered the gene expression to an inductive hair follicle dermal papilla fibroblast-like profile and activated Igf and Wnt signaling, which are crucial for the regeneration process. Therefore, a cocktail of organ-specific extracellular proteins from the embryonic environment can render adult cells competent to re-engage in developmental interactions for organ neogenesis. Identification of factors that recreate the extracellular context of respective developing tissues can become an important strategy to promote regeneration in adult organs. (C) 2018 Elsevier Ltd. All rights reserved.
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