期刊
BIOMATERIALS
卷 177, 期 -, 页码 40-51出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2018.05.055
关键词
Cu-layered double hydroxides; T-1-weighted MRI contrast agents; Acid-enhanced photothermal therapy; pH-sensitive theranostic agents; Tumor microenvironment
资金
- National Health and Medical Research Council of Australia (NHMRC) Early Career Fellowship [APP1073591]
- Australian Research Council (ARC) Discovery Project [DP170104643]
- Australian Government Research Training Program Scholarship (RTP)
Non-invasive imaging-guided tumor therapy requires new-generation bio-nanomaterials to sensitively respond to the unique tumor microenvironment for precise diagnosis and efficient treatment. Here, we report such a theranostic nanoplatform by engineering defect-rich multifunctional Cu-doped layered double hydroxide (Cu-LDH) nanoparticles, which integrates pH-sensitive T-1-magnetic resonance imaging (MRI), acid-enhanced photothermal therapy and heat-facilitated chemotherapy. As characterized with EXAFS and XPS, smaller Cu-LDH nanoparticles possess a considerable amount of defects around Cu cations, an advantageous microstructure that enables a high photothermal conversion of 808 nm NIR laser (53.1%). The exposure of Cu-OH octahedra on the LDH surface makes the photothermal conversion significantly acid-enhanced (53.1% at pH 7.0 vs. 81.9% at pH 5.0). This Cu peculiar microstructure also makes T-1-MRI very pH-sensitive, a desirable guide for subsequent tumor photothermal therapy. Combined photothermal therapy and chemotherapy lead to nearly complete elimination of tumor tissues in vivo with a low injection dose of agents. Therefore, this novel defect-rich Cu-LDH nanoplatform is one of promising tumor-specific nanotheranostic agents for non-invasive imaging-guided combinational therapy. (C) 2018 Elsevier Ltd. All rights reserved.
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