期刊
BIOMATERIALS
卷 175, 期 -, 页码 123-133出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2018.05.018
关键词
Hypoxia tumor; Nanotheranostics; Chemotherapy; Magnetic resonance imaging; Nanotechnology
资金
- China National Funds for Distinguished Young Scientists [51725202]
- National Natural Science Foundation of China [51702211, 81671732]
- Shanghai Excellent Academic Leaders Program [16XD1404000]
Hypoxia, as an inevitable characteristic of solid tumors, has been regarded as a noticeably causative factor to therapeutic resistance and metastatic variants. Exploring novel theranostics to realize the accurate diagnosis of hypoxia and the simultaneous implementation of effective therapy is a promising prospect for the successful treatment of tumors. In the present study, we designed and synthesized a multifunctional rattle-structured nanotheranostic, with the inner core coated by hollow mesoporous silica for chemical drug Doxorubicin (DOX) storage and hypoxia-sensitive MnO2 enrichment. In various acidic micro-environments caused by hypoxia, MnO2 nanosheets could be degraded into manganese ions (Mn2+), which were chelated by the modified Tetraxetanum (DOTA) ligands for real-time Ti-magnetic resonance imaging (T1-MRI), with on-demand DOX release to realize both normoxia and hypoxiasensitive chemotherapy by overcoming hypoxia. Nanotheranostics integrating hypoxia-driven T1-MRI with synergetic chemotherapy have tremendous potential in the intelligent diagnosis, personalized treatment and excellent prognosis of solid tumors in the future. (C) 2018 Elsevier Ltd. All rights reserved.
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