期刊
BIOMARKERS IN MEDICINE
卷 12, 期 1, 页码 11-20出版社
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2017-0114
关键词
biomarker; CircRNA; diagnostics; divergent primers; gastric cancer; gene expression; Hsa_circ_0074362; noncoding RNA; RT-PCR; translational medicine
资金
- Applied Research Project on Nonprofit Technology of Zhejiang Province [2016C33177]
- Scientific Innovation Team Project of Ningbo [2017C110019]
- National Natural Science Foundation of China [81772279]
- K. C. Wong Magna Fund in Ningbo University
Aim: To explore the diagnostic value of hsa_circ_0074362 in the screening of gastric cancer. Methods: The expression levels of hsa_circ_0074362 in 127 gastric cancer tissues and paired adjacent normal tissues, 83 gastritis tissues and six gastric cancer cell lines were first detected by quantitative reverse transcription-polymerase chain reaction. Then, the relationship between its levels and clinicopathological factors of patients with gastric cancer was analyzed. Finally, a receiver operating characteristic curve was established. Results: Hsa_circ_0074362 levels were significantly downregulated in gastric cancer tissues, gastritis tissues and gastric cancer cell lines. Its levels were associated with lymphatic metastasis. Conclusion: Hsa_circ_0074362 probably plays a role in the initiation of gastric cancer and may be a potential biomarker of gastric cancer.
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