期刊
BIOMACROMOLECULES
卷 19, 期 6, 页码 1732-1745出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.8b00218
关键词
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资金
- National Key R&D Program of China [2017YFA0205400]
- Natural Science Foundation of China [51690153, 21474045, 21720102005, 51422303]
- Program for Changjiang Scholars and Innovative Research Team in University
Most nanocarriers possess low drug loading, resulting in frequently repeated administration and thereby high cost and increased side effects. Furthermore, the characteristics of nanocarrier materials, especially the drug loading capacity, plays a vital role in the drug delivery efficacy. In this review, we focus on the readily translatable polymeric drug delivery systems with high drug loading, which are comprised of biocompatible polymers such as poly(ethylene glycol), poly(N-vinylpyrrolidone), polyoxazoline, natural proteins like albumin and casein, non-natural proteins such as recombinant elastin-like polypeptides, as well as nucleic acids. At the end of this review, applications of these polymeric nanocarriers on the delivery of proteins and gene drugs are also briefly discussed.
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