期刊
BIOLOGY OF REPRODUCTION
卷 99, 期 5, 页码 922-937出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/biolre/ioy109
关键词
preterm birth; mouse models; pregnancy; gestation; parturition
资金
- NIH [HD081121, HD088830, HL132805]
- March of Dimes Prematurity Research Center
- Department of Obstetrics and Gynecology at Washington University
Preterm birth affects approximately 1 out of every 10 births in the United States, leading to high rates of mortality and long-term negative health consequences. To investigate the mechanisms leading to preterm birth so as to develop prevention strategies, researchers have developed numerous mouse models of preterm birth. However, the lack of standard definitions for preterm birth in mice limits our field's ability to compare models and make inferences about preterm birth in humans. In this review, we discuss numerous mouse preterm birth models, propose guidelines for experiments and reporting, and suggest markers that can be used to assess whether pups are premature or mature. We argue that adoption of these recommendations will enhance the utility of mice as models for preterm birth. Summary Sentence To improve reporting of mouse models of preterm birth, a set of universal guidelines and simple assays of developmental markers are proposed to distinguish between mature and premature pups.
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