期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 24, 期 1, 页码 71-77出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2017.08.028
关键词
Dendritic cell vaccine; Immunotherapy; Cytomegalovirus; Donor lymphocytes
资金
- Leukaemia Foundation of Australia PhD (Clinical) Scholarship
- National Health and Medical Research Council of Australia fellowship
Adoptive cellular immunotherapy has been shown to be effective in the management of cytomegalovirus (CMV) reactivation and disease. Whether adjuvant dendritic cell (DC) vaccination will provide additional benefit in prophylaxis or treatment of CMV in hematoietic cell transplantation (HSCT) recipients is unknown. In this study, we administered prophylactic CMV-peptide specific T cell infusions, followed by 2 doses of intradermal CMV peptide-pulsed DC vaccine, to 4 HSCT recipients. There were no immediate adverse events associated with T cell infusion or DC vaccinations. One of the 4 patients developed grade III acute gut graft-versus-host disease. Immune reconstitution against CMV was detected in all 4 patients. Patients receiving CMV peptide specific T cells and DC vaccination had peak immune reconstitution at least 10 days after the second DC vaccination. In summary, combining DC vaccine with T cell infusion appears feasible, although further study is required to ascertain its safety and efficacy in augmenting the effects of infusing donor-derived CMV-specific T cells. (C) 2017 American Society for Blood and Marrow Transplantation.
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