期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 24, 期 9, 页码 1841-1847出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2018.05.007
关键词
Natural killer cells; Immune recovery; Immune reconstitution; Lymphocyte subset; Allogeneic hematopoietic stem cell transplantation
Rapid immune recovery following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is important for clinical outcome prediction. In most studies, immune recovery after allo-HSCT is monitored via peripheral blood. However, few reports regarding the status of absolute lymphocyte subsets in the bone marrow (BM) microenvironment have been undertaken. Therefore, we evaluated the clinical impact of immune recovery in the early period following allo-HSCT using BM samples. We showed that delayed natural killer cell recovery was independently associated with a poor prognosis for overall survival (hazard ratio [HR], 3.07; 95% confidence interval [CI], 1.37-6.89; P=.007), progression -free survival (HR, 3.42; 95% CI, 1.47-7.94; P=.004), and nonrelapse mortality (HR, 6.68; 95% CI, 1.82-25.0; P =.004) by multivariate analysis. In addition, lowNM cell counts were associated with the presence of 1 or more bacterial, viral, or fungal infections. Our results indicate that investigating absolute lymphocyte subsets in BM in the early phase following allo-HSCT can be useful for predicting and improving survival outcomes. (C) 2018 American Society for Blood and Marrow Transplantation.
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