期刊
BIOLOGICAL TRACE ELEMENT RESEARCH
卷 186, 期 2, 页码 407-412出版社
HUMANA PRESS INC
DOI: 10.1007/s12011-018-1308-z
关键词
Zinc; Insulin resistance; Insulin sensitivity; Insulin secretion; Supplementation
Studies have shown the participation of minerals in mechanisms involved in the pathogenesis of insulin resistance. Zinc, in particular, seems to play an important role in the secretion and action of this hormone. Therefore, the aim of this review is to understand the role of zinc in increasing insulin sensitivity. We conducted a search of articles published in the PubMed and ScienceDirect database selected from March 2016 to February 2018, using the keywords zinc, insulin, insulin resistance, insulin sensitivity, and supplementation. Following the eligibility criteria were selected 53 articles. The scientific evidences presented in this review show the importance of zinc and their carrier proteins in the synthesis and secretion of insulin, as well as in the signaling pathway of action of this hormone. Zinc deficiency is associated with glucose intolerance and insulin resistance; however, the effectiveness of the intervention with the zinc supplementation is still inconclusive.
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