期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 24, 页码 13612-13619出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b03230
关键词
MW thermotherapy; tumor; gelatin microcapsules; MR imaging-guided; ionic liquid
资金
- National Hi-Technology Research and Development Program (863 Program) [2013AA032201, 2012AA022701]
- National Natural Science Foundation of China (NSFC) [61171049, 31400854, 81201814]
The combination of therapies and monitoring the treatment process has become a new concept in cancer therapy. Herein, gelatin-based microcapsules have been first reported to be used as microwave (MW) susceptible agent and magnetic resonance (MR) imaging contrast agent for cancer MW thermotherapy. Using the simple coacervation methods, ionic liquid (IL) and Fe3O4 nanoparticles (NPs) were wrapped in microcapsules, and these microcapsules showed good heating efficacy in vitro under MW irradiation. The results of cell tests indicated that gelatin/IL@Fe3O4 microcapsules possessed excellent compatibility in physiological environments, and they could effectively kill cancer cells with exposure to MW. The ICR mice bearing H22 tumors treated with gelatin/IL@Fe3O4 microcapsules were obtained an outstanding MW thermotherapy efficacy with 100% tumor elimination under ultralow density irradiation (1.8 W/cm(2), 450 MHz). In addition, the applicability of the microcapsules as an efficient contrast agent for MR imaging in vivo was evident. Therefore, these multifunctional microcapsules have a great potential for MR imaging-guided MW thermotherapy.
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