期刊
BIOLOGICAL CHEMISTRY
卷 399, 期 2, 页码 147-178出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2017-0228
关键词
autophagy; mitophagy; Mito-QC; mitoTimer; mt-Keima; Parkin
资金
- NIH [R01 AA020518, R01 DK102142, U01 AA024733, P20GM103549, P30GM118247]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK102142] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P20GM103549, P20GM103541, P30GM118247] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [U01AA024733, R37AA020518, R01AA020518] Funding Source: NIH RePORTER
In 2012, we briefly summarized the mechanisms, pathophysiological roles and methods for analyzing mitophagy. As then, the mitophagy field has continued to grow rapidly, and many new molecular mechanisms regulating mitophagy and molecular tools for monitoring mitophagy have been discovered and developed. Therefore, the purpose of this review is to update information regarding these advances in mitophagy while focusing on basic molecular mechanisms of mitophagy in different organisms and its pathophysiological roles. We also discuss the advantage and limitations of current methods to monitor and quantify mitophagy in cultured cells and in vivo mouse tissues.
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