期刊
BIOINFORMATICS
卷 34, 期 12, 页码 2116-2122出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/bty040
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类别
资金
- French agency for food and safety [ANSES] [EST-13-081]
- Fondation pour la recherche medicale [FRM] [DBI20131228558]
- European Union [FEDER]
- Institut national de la sante et de la recherche medicale (Inserm)
- l'Universite de Rennes 1
Motivation: At the same time that toxicologists express increasing concern about reproducibility in this field, the development of dedicated databases has already smoothed the path toward improving the storage and exchange of raw toxicogenomic data. Nevertheless, none provides access to analyzed and interpreted data as originally reported in scientific publications. Given the increasing demand for access to this information, we developed TOXsIgN, a repository for TOXicogenomic sIgNatures. Results: The TOXsIgN repository provides a flexible environment that facilitates online submission, storage and retrieval of toxicogenomic signatures by the scientific community. It currently hosts 754 projects that describe more than 450 distinct chemicals and their 8491 associated signatures. It also provides users with a working environment containing a powerful search engine as well as bioinformatics/biostatistics modules that enable signature comparisons or enrichment analyses.
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