期刊
BIOESSAYS
卷 40, 期 5, 页码 -出版社
WILEY
DOI: 10.1002/bies.201700229
关键词
double-strand break repair; DNA strand invasion; homologous recombination; Rad51/RecA; search for homology
资金
- Institute of General Medicine of the NIH
The repair of chromosomal double-strand breaks (DSBs) by homologous recombination is essential to maintain genome integrity. The key step in DSB repair is the RecA/Rad51-mediated process to match sequences at the broken end to homologous donor sequences that can be used as a template to repair the lesion. Here, in reviewing research about DSB repair, I consider the many factors that appear to play important roles in the successful search for homology by several homologous recombination mechanisms.
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