期刊
BIODRUGS
卷 32, 期 4, 页码 297-309出版社
ADIS INT LTD
DOI: 10.1007/s40259-018-0290-5
关键词
-
资金
- National Institute of General Medical Sciences of the National Institutes of Health [R35GM119659]
- Department of Defense
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R35GM119659] Funding Source: NIH RePORTER
Spherical nucleic acids (SNAs) are highly oriented, well organized, polyvalent structures of nucleic acids conjugated to hollow or solid core nanoparticles. Because they can transfect many tissue and cell types without toxicity, induce minimum immune response, and penetrate various biological barriers (such as the skin, blood-brain barrier, and blood-tumor barrier), they have become versatile tools for the delivery of nucleic acids, drugs, and proteins for various therapeutic purposes. This article describes the unique structures and properties of SNAs and discusses how these properties enable their application in gene regulation, immunomodulation, and drug and protein delivery. It also summarizes current efforts towards clinical translation of SNAs and provides an expert opinion on remaining challenges to be addressed in the path forward to the clinic.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据