期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1864, 期 6, 页码 2034-2039出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2018.03.018
关键词
Rheumatoid arthritis; Immunoglobulin G; N-glycans; Biomarker; Risk factor
资金
- European grant SYSCID [733100]
- European grant GlySign [722095]
- European grant IMForFuture [721815]
- European Structural and Investment Funds IRI [KK.01.2.1.01.0003]
- Croatian National Centre of Research Excellence in Personalized Healthcare [KK.01.1.1.01.0010]
- Finnish Academy [269517]
- Yrjo Jahnsson Foundation
- Juho Vainio Foundation
- Aarne Koskelo Foundation
- Ida Montin Foundation
- Biomedicum Helsinki Foundation
- Finnish Foundation for Cardiovascular Research
- Integrative Life Science Doctoral Program of the University of Helsinki
Antibodies are known to have an important role in the development of rheumatoid arthritis (RA), one of the most prevalent chronic inflammatory diseases which primarily involves the joints. Most RA patients develop auto antibodies against immunoglobulin G (IgG) and changes in IgG glycosylation have been associated with RA. We undertook this study to determine whether altered IgG glycosylation precedes the disease diagnosis. We studied IgG glycosylation in RA in two prospective cohorts (N = 14,749) by measuring 28 IgG glycan traits in 179 subjects who developed RA within 10-years follow-up and 358 matched controls. Ultra-performance liquid chromatography method based on hydrophilic interactions (HILIC-UPLC) was used to analyse IgG glycans. Future RA diagnosis associated with traits related to lower galactosylation and sialylation of IgG when comparing the cases to the matched controls. In RA cases, these traits did not correlate with the time between being recruited to the study and being diagnosed with RA (median time 4.31 years). The difference in IgG glycosylation was relatively stable and present years before diagnosis. This indicates that long-acting factors affecting IgG glycome composition are among the underlying mechanisms of RA and that decreased galactosylation is a preexisting risk factor involved in the disease development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据