期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1864, 期 1, 页码 189-196出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2017.10.011
关键词
Asthma; IgE; Fc epsilon R1(-/-); Hypotension
资金
- National Natural Science Foundation of China [81622008, 81470579]
- Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences [2016-I2M-1-006]
- Thousand Young Talents Program of China
- Peking Union Medical College Youth Fund/the Fundamental Research Funds for the Central University [3332016048]
Immunoglobulin E (IgE) has been suggested as a risk factor for allergy-induced low blood pressure, which has not been well explained in molecular details. Our current study shows a novel mechanism involving IgE, Fc epsilon R1, miRNA-212-5p (miR-212-5p), and sodium/calcium exchanger protein 1(NCX1) for asthma to induce hypotension. In arterial smooth muscle cells, IgE up-regulated miR212-5p via its receptor FceR1, which resulted in down regulation of NCX1 that is a regulating factor for blood pressure. In mice, asthma induced hypotension by interfering vasoconstrictive function; knockout of FceR1 kept the asthmatic mice from developing hypotension; knock-down of miR-212-5p in asthmatic mice resulted in a significant restoration of blood pressure. In human, asthma and IgE were positively correlated with hypotension in cohort study on NIH epidemiological data. This study suggests a novel therapeutic target (miR-212-5p) for treatment of asthma-induced hypotension.
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