期刊
FERTILITY AND STERILITY
卷 103, 期 1, 页码 264-269出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2014.09.042
关键词
GnRHa trigger; PCOS; IVF outcomes; OHSS
资金
- National Institues of Health [T32 PD10032525, 5K12HD001265-14]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [K12HD001265] Funding Source: NIH RePORTER
Objective: To compare endocrine profiles and IVF outcomes after using GnRH agonists (GnRHa) to trigger final oocyte maturation in women with polycystic ovary syndrome (PCOS) with other hyper-responders. Design: Retrospective cohort study. Setting: Academic center. Patient(s): Forty women with PCOS and 74 hyper-responders without PCOS. Intervention(s): GnRHa trigger. Main Outcome Measure(s): Number of oocytes. Result(s): Serum E-2, LH, and P levels on the day of GnRHa trigger and the day after trigger did not differ significantly between groups. There were no significant differences in total number of oocytes or percent mature oocytes obtained between groups after controlling for age, antral follicle count, and total days of stimulation. The overall rate of no retrieval of oocytes after trigger was low (2.6%). Fertilization, implantation, clinical pregnancy, and live-birth rates were similar in the two groups. No patients developed ovarian hyperstimulation syndrome (OHSS). Conclusion(s): The similar post-GnRHa trigger hormone profiles and mature oocyte yield support the routine use of GnRHa trigger to prevent OHSS in women with PCOS. (C)2015 by American Society for Reproductive Medicine.
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