期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
卷 1859, 期 4, 页码 263-269出版社
ELSEVIER
DOI: 10.1016/j.bbabio.2018.01.005
关键词
OPA1; Long and short OPA1 forms; Mitochondrial network dynamics; Cristae; mtDNA; Energetics
资金
- FIR grant from the Ministero della Istruzione University e Ricerca (MIUR) [RBFR131WDS]
OPA1 is a dynamin-related GTPase that controls mitochondrial dynamics, cristae integrity, energetics and mtDNA maintenance. The exceptional complexity of this protein is determined by the presence, in humans, of eight different isoforms that, in turn, are proteolytically cleaved into combinations of membrane-anchored long forms and soluble short forms. Recent advances highlight how each OPA1 isoform is able to fulfill essential mitochondrial functions, whereas only some variants carry out specialized features. Long forms determine fusion, long or short forms alone build cristae, whereas long and short forms together tune mitochondrial morphology. These findings offer novel challenging therapeutic potential to gene therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据