期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 46, 期 -, 页码 491-501出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20170388
关键词
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资金
- PRESTO, Japan Science and Technology Agency [JPMJPR15F7]
- Japan Society for the Promotion of Science [24687022, 26650055, 23115005]
- Takeda Science Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- RIKEN Foreign Postdoctoral Researcher fellowship
- Grants-in-Aid for Scientific Research [26650055, 24687022] Funding Source: KAKEN
Nucleosomes are the unitary structures of chromosome folding, and their arrangements are intimately coupled to the regulation of genome activities. Conventionally, structural analyses using electron microscopy and X-ray crystallography have been used to study such spatial nucleosome arrangements. In contrast, recent improvements in the resolution of sequencing-based methods allowed investigation of nucleosome arrangements separately at each genomic locus, enabling exploration of gene-dependent regulation mechanisms. Here, we review recent studies on nucleosome folding in chromosomes from these two methodological perspectives: conventional structural analyses and DNA sequencing, and discuss their implications for future research.
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