相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。PINK1 suppresses alpha-synuclein-induced neuronal injury: a novel mechanism in protein phosphatase 2A activation
Weiwei Yang et al.
ONCOTARGET (2018)
Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs
Diego Mastroeni et al.
ALZHEIMERS & DEMENTIA (2018)
Synthesis and evaluation of 2-(3-arylureido)pyridines and 2-(3-arylureido)pyrazines as potential modulators of Aβ-induced mitochondrial dysfunction in Alzheimer's disease
Ahmed Elkamhawy et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton
Dalila G. Ordonez et al.
NEURON (2018)
TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics
Stephani A. Davis et al.
NEUROSCIENCE LETTERS (2018)
Cardiolipin exposure on the outer mitochondrial membrane modulates alpha-synuclein
Tammy Ryan et al.
NATURE COMMUNICATIONS (2018)
Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity
Jung-eun Park et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Interactions between Tau and Different Conformations of Tubulin: Implications for Tau Function and Mechanism
Aranda R. Duan et al.
JOURNAL OF MOLECULAR BIOLOGY (2017)
Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage
Veronica Lindstrom et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2017)
αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson's disease
Victorio Martin Pozo Devoto et al.
SCIENTIFIC REPORTS (2017)
Antioxidants in Central Nervous System Diseases: Preclinical Promise and Translational Challenges
Chandrashekhar D. Kamat et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability
Thomas Briston et al.
SCIENTIFIC REPORTS (2017)
PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer's disease
Fang Du et al.
BRAIN (2017)
N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore
Sudeshna Roy et al.
CHEMMEDCHEM (2016)
Defective PITRM1 mitochondrial peptidase is associated with A amyloidotic neurodegeneration
Dario Brunetti et al.
EMBO MOLECULAR MEDICINE (2016)
Quantification of active mitochondrial permeability transition pores using GNX-4975 inhibitor titrations provides insights into molecular identity
Andrew P. Richardson et al.
BIOCHEMICAL JOURNAL (2016)
Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease
Chung-Han Hsieh et al.
CELL STEM CELL (2016)
Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers
Cathryn L. Ugalde et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Mitochondrial dysfunction in Parkinson's disease
Anindita Bose et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Amyloid β-peptides interfere with mitochondrial preprotein import competence by a coaggregation process
Giovanna Cenini et al.
MOLECULAR BIOLOGY OF THE CELL (2016)
Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease
Zoi Alexopoulou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease
Roberto Di Maio et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Identification of a Small Molecule Cyclophilin D Inhibitor for Rescuing Aβ-Mediated Mitochondrial Dysfunction
Koteswara Rao Valasani et al.
ACS MEDICINAL CHEMISTRY LETTERS (2016)
Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease
Simon J. Beck et al.
NATURE COMMUNICATIONS (2016)
Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin
Yu Hu et al.
ONCOTARGET (2016)
Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins
Xia-Chun Li et al.
SCIENTIFIC REPORTS (2016)
Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria
Thomas Briston et al.
SCIENTIFIC REPORTS (2016)
Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation
Sun Young Chung et al.
STEM CELL REPORTS (2016)
Deubiquitinating enzymes regulate PARK2-mediated mitophagy
Yuqing Wang et al.
AUTOPHAGY (2015)
Proteinopathies, a core concept for understanding and ultimately treating degenerative disorders?
Thomas A. Bayer
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2015)
NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease
V. Corsetti et al.
HUMAN MOLECULAR GENETICS (2015)
F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy
Zhi Dong Zhou et al.
HUMAN MOLECULAR GENETICS (2015)
Mitochondria: A Therapeutic Target for Parkinson's Disease?
Yu Luo et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)
Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α-synuclein in oligodendroglial cells
Katharina Pukass et al.
JOURNAL OF NEUROCHEMISTRY (2015)
A53T Human α-Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration
Linan Chen et al.
JOURNAL OF NEUROSCIENCE (2015)
USP30: A New Promising Target for Parkinson's Disease?
S. Thobois
MOVEMENT DISORDERS (2015)
USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
Christian N. Cunningham et al.
NATURE CELL BIOLOGY (2015)
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson's Disease
Alicia M. Pickrell et al.
NEURON (2015)
Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression
Suzana Gispert et al.
HUMAN MOLECULAR GENETICS (2015)
Amyloid-beta Peptides are Generated in Mitochondria-Associated Endoplasmic Reticulum Membranes
Bernadette Schreiner et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
α-Synuclein amino terminus regulates mitochondrial membrane permeability
Jiamei Shen et al.
BRAIN RESEARCH (2014)
Mitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?
H. Muyderman et al.
BRITISH JOURNAL OF PHARMACOLOGY (2014)
A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30
Wen Yue et al.
CELL RESEARCH (2014)
Loss of the m-AAA protease subunit AFG3L2 causes mitochondrial transport defects and tau hyperphosphorylation
Arun Kumar Kondadi et al.
EMBO JOURNAL (2014)
USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin
Thomas M. Durcan et al.
EMBO JOURNAL (2014)
The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease
Li Fang Ng et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis
Ernesto Miquel et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
Parkin overexpression ameliorates hippocampal long-term potentiation and β-amyloid load in an Alzheimer's disease mouse model
Xiaoqi Hong et al.
HUMAN MOLECULAR GENETICS (2014)
Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice
Chen Wenqiang et al.
HUMAN MOLECULAR GENETICS (2014)
The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy
Tom Cornelissen et al.
HUMAN MOLECULAR GENETICS (2014)
Down-regulation of Mortalin Exacerbates Aβ-mediated Mitochondrial Fragmentation and Dysfunction
So Jung Park et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Cinnamic Anilides as New Mitochondrial Permeability Transition Pore Inhibitors Endowed with Ischemia-Reperfusion Injury Protective Effect in Vivo
Daniele Fancelli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance
Irina Lonskaya et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2014)
alpha-Synuclein Is Localized to Mitochondria-Associated ER Membranes
Cristina Guardia-Laguarta et al.
JOURNAL OF NEUROSCIENCE (2014)
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
Baris Bingol et al.
NATURE (2014)
AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons
G. Amadoro et al.
NEUROBIOLOGY OF DISEASE (2014)
GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis
Lee J. Martin et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease-Links to Parkinson's Disease
Laura D. Osellame et al.
CELL METABOLISM (2013)
Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance
Irina Lonskaya et al.
EMBO MOLECULAR MEDICINE (2013)
Synthesis and evaluation of oxime derivatives as modulators for amyloid beta-induced mitochondrial dysfunction
Young Seub Kim et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons
Wenzhang Wang et al.
HUMAN MOLECULAR GENETICS (2013)
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy
Victoria S. Burchell et al.
NATURE NEUROSCIENCE (2013)
Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer's Neurons
Lan Guo et al.
PLOS ONE (2013)
Dimers of mitochondrial ATP synthase form the permeability transition pore
Valentina Giorgio et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin
Michael Lazarou et al.
DEVELOPMENTAL CELL (2012)
Mitochondria-targeted catalase reduces abnormal APP processing, amyloid production and BACE1 in a mouse model of Alzheimers disease: implications for neuroprotection and lifespan extension
Peizhong Mao et al.
HUMAN MOLECULAR GENETICS (2012)
Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimers disease
Maria Manczak et al.
HUMAN MOLECULAR GENETICS (2012)
Interaction between NH2-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration
Giuseppina Amadoro et al.
NEUROBIOLOGY OF AGING (2012)
Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo
Brian DuBoff et al.
NEURON (2012)
Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease-Related Tau Phosphorylation Via PAR-1
Kanae Iijima-Ando et al.
PLOS GENETICS (2012)
Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration
Carsten Merkwirth et al.
PLOS GENETICS (2012)
Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain
Katherine J. Kopeikina et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Mortalin overexpression attenuates beta-amyloid-induced neurotoxicity in SH-SY5Y cells
Mingyue Qu et al.
BRAIN RESEARCH (2011)
Mitochondria: The Common Upstream Driver of Amyloid-β and Tau Pathology in Alzheimers Disease
D. F.F. Silva et al.
Current Alzheimer Research (2011)
FTD and ALS: A Tale of Two Diseases
R. Ferrari et al.
CURRENT ALZHEIMER RESEARCH (2011)
Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Aβ in AD models
Preeti J. Khandelwal et al.
HUMAN MOLECULAR GENETICS (2011)
α-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator
Yuangang Zhu et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2011)
Decreased Proteolytic Activity of the Mitochondrial Amyloid-beta Degrading Enzyme, PreP Peptidasome, in Alzheimer's Disease Brain Mitochondria
Nyosha Alikhani et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
Ken Nakamura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease
Meagan J. McManus et al.
JOURNAL OF NEUROSCIENCE (2011)
Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model
Heng Du et al.
NEUROBIOLOGY OF AGING (2011)
α-Synuclein fate is determined by USP9X-regulated monoubiquitination
Ruth Rott et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
FUS Transgenic Rats Develop the Phenotypes of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration
Cao Huang et al.
PLOS GENETICS (2011)
Extensive FUS-Immunoreactive Pathology in Juvenile Amyotrophic Lateral Sclerosis with Basophilic Inclusions
Eric J. Huang et al.
BRAIN PATHOLOGY (2010)
The dysregulation of intracellular calcium in Alzheimer disease
Charlene Supnet et al.
CELL CALCIUM (2010)
Calcium-dependent mitochondrial function and dysfunction in neurons
Natalia B. Pivovarova et al.
FEBS JOURNAL (2010)
Neuronal Calcium Signaling, Mitochondrial Dysfunction, and Alzheimer's Disease
Charlene Supnet et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
A NH2 Tau Fragment Targets Neuronal Mitochondria at AD Synapses: Possible Implications for Neurodegeneration
Giuseppina Amadoro et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice
Ya-Fei Xu et al.
JOURNAL OF NEUROSCIENCE (2010)
TRO40303, a New Cardioprotective Compound, Inhibits Mitochondrial Permeability Transition
Sophie Schaller et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
Martin Schwickart et al.
NATURE (2010)
Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
Shankar J. Chinta et al.
NEUROSCIENCE LETTERS (2010)
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
Han Seok Ko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice
Xiu Shan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects in Col6a1-/- myopathic mice
T. Tiepolo et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Amyloid-beta Leads to Impaired Cellular Respiration, Energy Production and Mitochondrial Electron Chain Complex Activities in Human Neuroblastoma Cells
V. Rhein et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2009)
Parkin promotes intracellular Aβ1-42 clearance
Mark P. Burns et al.
HUMAN MOLECULAR GENETICS (2009)
Cyclophilin D Modulates Mitochondrial F0F1-ATP Synthase by Interacting with the Lateral Stalk of the Complex
Valentina Giorgio et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport
Will Stoothoff et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
Virginie Rhein et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mitochondrial import and accumulation of α-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain
Latha Devi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Derek Narendra et al.
JOURNAL OF CELL BIOLOGY (2008)
Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane
Nobuhiro Nakamura et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
Heng Du et al.
NATURE MEDICINE (2008)
Study of subcellular localization and proteolysis of ataxin-3
Chiara Pozzi et al.
NEUROBIOLOGY OF DISEASE (2008)
The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
Camilla A. Hansson Petersen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau
Simon Melov et al.
PLOS ONE (2007)
Degradation of the amyloid β-protein by the novel mitochondrial peptidasome, PreP
Annelie Falkevall et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused inactivation of Drosophila Pink1 is rescued by by Parkin
Yufeng Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Ira E. Clark et al.
NATURE (2006)
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
Jeehye Park et al.
NATURE (2006)
Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled
Paula M. Keeney et al.
JOURNAL OF NEUROSCIENCE (2006)
Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
LJ Martin et al.
JOURNAL OF NEUROSCIENCE (2006)
Properties of the permeability transition pore in mitochondria devoid of cyclophilin D
E Basso et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
CP Baines et al.
NATURE (2005)
The nonimmunosuppressive cyclosporin analogs NIM811 and UNIL025 display nanomolar potencies on permeability transition in brain-derived mitochondria
MJ Hansson et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2004)
Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication
PE Coskun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease - Implications for early mitochonrial dysfunction and oxidative damage
M Manczak et al.
NEUROMOLECULAR MEDICINE (2004)
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
EM Valente et al.
SCIENCE (2004)
Induction of cytochrome c-mediated apoptosis by amyloid β 25-35 requires functional mitochondria
SM Cardoso et al.
BRAIN RESEARCH (2002)
High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
MT Lin et al.
HUMAN MOLECULAR GENETICS (2002)
Selective targeting of a redox-active ubiquinone to mitochondria within cells - Antioxidant and antiapoptotic properties
GF Kelso et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
α-synuclein promotes mitochondrial deficit and oxidative stress
LJ Hsu et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
分享论文
