期刊
BIOCHEMICAL PHARMACOLOGY
卷 151, 期 -, 页码 307-313出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2018.02.002
关键词
Adenosine; Adenosine receptor; Adenosine metabolism; Osteoarthritis; Type 2 immunity; Fibrosis
资金
- National Institutes of Health [R01GM066189, R01DK113790, R41GM120838, R01 AR056672, R01 AR068593]
- NYU-HHC CTSI [1UL1TR001445]
- Arthritis Foundation
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000038, UL1TR001445] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR068593, R01AR056672] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK113790] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R41GM120838, R01GM066189] Funding Source: NIH RePORTER
The purine nucleoside adenosine is a present in most body fluids where it regulates a wide variety of physiologic and pharmacologic processes. Adenosine mediates its effects through activating 4 G protein-coupled receptors expressed on the cell membrane: A1, A2A, A2B, and A3. The adenosine receptors are widely distributed in the body, and tissues with high expression include immune tissues, cartilage, bone, heart, and brain. Here we review the source and metabolism of adenosine and the role of adenosine in regulating immunity and cartilage biology.
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