期刊
BIOCHEMICAL PHARMACOLOGY
卷 147, 期 -, 页码 211-220出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2017.10.006
关键词
Exercise; Skeletal muscle; AMPK; mTOR; PPAR beta/delta; PGC-1 alpha; Dietary supplements; Exercise mimetics
资金
- Swiss National Science Foundation
- European Research Council (ERC) [616830-MUSCLE_NET]
- Swiss Cancer Research [KFS-3733-08-2015]
- Swiss Society for Research on Muscle Diseases (SSEM)
- SystemsX.ch
- Novartis Stiftung fur Medizinisch-Biologische Forschung
- University of Basel
Exercise exerts significant effects on the prevention and treatment of many diseases. However, even though some of the key regulators of training adaptation in skeletal muscle have been identified, this biological program is still poorly understood. Accordingly, exercise-based pharmacological interventions for many muscle wasting diseases and also for pathologies that are triggered by a sedentary lifestyle remain scarce. The most efficacious compounds that induce muscle hypertrophy or endurance are hampered by severe side effects and are classified as doping. In contrast, dietary supplements with a higher safety margin exert milder outcomes. In recent years, the design of pharmacological agents that activate the training program, so-called exercise mimetics, has been proposed, although the feasibility of such an approach is highly debated. In this review, the most recent insights into key regulatory factors and therapeutic approaches aimed at leveraging exercise adaptations are discussed. (C) 2017 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据